Taking the consumption rate of renewable energy and the operation cost of hybrid AC/DC microgrid as the optimization objectives, the adjustment of load demand curves is carried out considering the demand side response (DSR) on the load side. The complementary utilization of renewable energy between AC area and DC area is achieved to meet the load demand on the source side. In the network side, the hybrid AC/DC microgrids purchase electricity from the power grid at the time-of-use (TOU) price and sell the surplus power of renewable energy to the power grid for profits. The improved memetic algorithm (IMA) is introduced and applied to solve the established mathematical model. The promotion effect of the proposed source-network-load coordination strategies on the optimal operation of hybrid AC/DC microgrid is verified.